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Background: COVID-19 is a serious pandemic the world is now facing and is associated with increasing morbidity and mortality. Medical students can act as reliable information providers in campaigns and enlightenment programmes. Assessment  of their knowledge and compliance is critical in this regard. This study aimed to determine COVID-19 related knowledge and practice of its preventive protocols among medical students of the University of Benin, NigeriaMethods: This descriptive cross-sectional study was conducted among 400Level to 600Level medical students during the second wave of the pandemic between June and July 2021 using a semi structured questionnaire that elicited information about socio-demographic details of the respondents, knowledge of COVID-19, compliance with prescribed preventive protocols and reasons for poor compliance. Data analysis was done using descriptive and Chi square statistics at a statistical significance level of p <0.05.Results: Of the one hundred and eighty- two medical students that took part in the study, 119 (65.4%) were males,101 (55.5%) and 97 (53.3%) had good knowledge of COVID-19 and its standard precautions respectively,110 (60.4%) reported good compliance with COVID-19 standard precautions while 72 (39.6%) of the respondents reported poor compliance with COVID19 standard precautions. Majority of the respondents (83.5%) attributed the reason for poor compliance with COVID-19 standard precautions to their religious faith and persuasion that they cannot have COVID-19. Among the tested independent variables, none was found to have statistically significant association with poor compliance with COVID-19 standard precautions. Conclusion: More than half of the medical students assessed in this study displayed good knowledge of COVID-19 infection, its standard precautions and good compliance with those standard precautions. Nonetheless, it is recommended that relevant stakeholders ensure improvement in their knowledge of the infection and its precautions as well as encourage better compliance with those preventive protocol. This is imperative, not only to reduce morbidity and mortality among them, but also to enhance effective and knowledge-based practice and enlightenment campaign delivery among the future doctors.

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